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http://path.upmc.edu/cases/case429/dx.html

Słów parę o Desmoplastic Melanoma w jęz. ang http://www.ncbi.nlm.nih.gov/pubmed/15731577

jeszcze

Cytat:

Desmoplastic melanoma is a rare subtype of melanoma that is locally aggressive and has a high rate of local recurrence. It most commonly develops on sun-exposed skin of the head and neck of elderly persons in the sixth or seventh decade of life. Desmoplastic melanoma has a male predominance ratio of approximately 2 : 1. Approximately one half of desmoplastic melanomas develop in association with a lentigo maligna. Desmoplastic melanoma can manifest clinically as a pigmented macule with or without a nodular component or as a flesh-colored nodule without any surrounding pigmentation. Desmoplastic melanomas often invade perineurally and are, therefore, often symptomatic. Most desmoplastic melanomas are deeply invasive at the time of diagnosis, at least 5 to 6 mm thick. They have a propensity to recur and deeply invade locally.

i jeszcze

Cytat:

Typically, it had been noted that desmoplastic melanoma demonstrated a better prognosis than other melanomas. The exception to this observation would be those DMs located in the head/neck. While they reported a 61% 5 year survival rate for DMs invading to a depth of >4mm, these same tumors when located in the head/neck worsened the 5-year survival rate to 38%. It has been postulated that the reason for this is that the thin layer of the dermis in this area allows faster access to the bloodstream and lymphatics, as well as the fact that cosmetically, this region may not allow for the clinician to achieve such wide surgical margins as necessary. They identified other poor prognostic factors, to include positivity for tyrosinase, melan-A and SMA staining, as well as tumor size and tumor thickness.

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